A Presque Isle ambulance crossed the centerline on Route 163 in Mapleton early Monday afternoon and hit two vehicles before leaving the roadway.
The crash sent two people to the hospital with injuries that were not considered life-threatening, according to Cpl. Nick Casavant of the Maine State Police.
A 2013 Ford Ambulance driven by Winston Reed, 40, of Presque Isle crossed the centerline while eastbound, and hit a westbound 2015 Kia Forte driven by Sonja Hutchinson, 37, of Ashland, according to police reports.
The ambulance then struck a 2020 Jeep Compass operated by Ryan Ashby, 34, of Mapleton, sending them both off of the road. All drivers were wearing their seatbelts at the time of the collisions, and speed was not a factor, police said.
Ashby and Reed were transported to Northern Light AR Gould to be treated for their injuries.
The cause of the crash had not been determined by late Monday afternoon.
That crash was one of eight that Maine State Police responded to between 8 a.m. and 1 p.m.
Two people were injured in two separate rollover crashes in addition to those injured in Mapleton, but they were not taken to the hospital, police said. Four of the crashes involved vehicles sliding off the road with no damage to the vehicles and no injuries.