This 2003 electron microscope image made available by the Centers for Disease Control and Prevention shows a monkeypox virion, obtained from a sample associated with the 2003 prairie dog outbreak. Credit: Cynthia S. Goldsmith and Russell Regner / CDC via AP

BOSTON — The Massachusetts Department of Public Health on Sunday reported two more cases of monkeypox in the state.

The two men who contracted monkeypox had close contact with each other, and are not believed to be linked to the state’s first case of monkeypox last month, officials said.

Monkeypox typically spreads by skin-to-skin contact, or contact with contaminated clothing or bedding. Most patients suffer fever, body aches, chills and fatigue. Others might develop a rash and lesions.

The disease is rarely fatal but health officials are keeping a close eye on it. The latest monkeypox patients are currently isolating themselves.

“It is very important to be aware of the symptoms of monkeypox and to be vigilant. Individuals with concerning rashes should contact their healthcare provider,” said Dr. Catherine Brown, state epidemiologist.

The latest U.S. data indicate there have been nearly 50 cases of monkeypox, including the first case in Massachusetts on May 18.