In this March 3, 2020, file photo, a man and his wife leave a COVID-19 vaccination site operated by MaineHealth in a site of a former department store in Sanford. Credit: Robert F. Bukaty / AP

Seven more Mainers have died while health officials on Wednesday reported there have been another 649 coronavirus cases across the state.

Wednesday’s report brings the total number of coronavirus cases in Maine to 99,256, according to the Maine Center for Disease Control and Prevention. That’s up from 98,607 on Tuesday.

Of those, 70,730 have been confirmed positive, while 28,256 were classified as “probable cases,” the Maine CDC reported.

Five women and two men have succumbed to the virus, bringing the statewide death toll to 1,109.

Three were from Cumberland County, two from Franklin County, one from Kennebec County and one from York County. Of those, six were 80 or older and one was in their 60s.

The number of coronavirus cases diagnosed in the past 14 days statewide is 6,055. This is an estimation of the current number of active cases in the state, as the Maine CDC is no longer tracking recoveries for all patients. That’s down from 6,242 on Tuesday.

The new case rate statewide Wednesday was 4.85 cases per 10,000 residents, and the total case rate statewide was 741.60.

Maine’s seven-day average for new coronavirus cases is 490.9, down from 528.1 the day before, up from 381.3 a week ago and up from 484.6 a month ago. That average peaked on Jan. 14 at 625.3.

The most cases have been detected in Mainers younger than 20, while Mainers over 80 years old make up the majority of deaths. More cases have been recorded in women and more deaths in men.

So far, 2,691 Mainers have been hospitalized at some point with COVID-19, the illness caused by the new coronavirus. Of those, 199 are currently hospitalized, with 68 in critical care and 34 on a ventilator. Overall, 47 out of 347 critical care beds and 191 out of 305 ventilators are available.

The total statewide hospitalization rate on Wednesday was 20.11 patients per 10,000 residents.

Cases have been reported in Androscoggin (10,471), Aroostook (3,736), Cumberland (21,443), Franklin (2,159), Hancock (2,667), Kennebec (9,470), Knox (1,872), Lincoln (1,751), Oxford (4,908), Penobscot (11,847), Piscataquis (1,280), Sagadahoc (1,918), Somerset (4,112), Waldo (2,332), Washington (1,755) and York (17,531) counties. Information about where an additional four cases were reported wasn’t immediately available.

An additional 2,156 vaccine doses were administered in the previous 24 hours. As of Wednesday, 897,047 Mainers are fully vaccinated, or about 75.7 percent of eligible Mainers, according to the Maine CDC.

New Hampshire reported 377 new cases on Wednesday and eight deaths. Vermont reported 132 new cases and one death, while Massachusetts reported 2,045 new cases and 26 deaths.

As of Wednesday morning, the coronavirus had sickened 45,150,490 people in all 50 states, the District of Columbia, Puerto Rico, Guam, the Northern Mariana Islands and the U.S. Virgin Islands, as well as caused 728,671 deaths, according to the Johns Hopkins University of Medicine.