ST. LOUIS — Brad Marchand scored twice and Tim Thomas stopped 30 shots to lead the Boston Bruins to a 4-2 win over St. Louis on Wednesday, ending the Blues’ team-record point streak at 21 home games.

Chris Stewart and Ryan Reaves scored for the Blues on the first five shots of the game, but Thomas stopped the next 27 shots to give the Blues their first regulation loss to an Eastern Conference team in 15 games this season.

St. Louis, 26-4-4 at home, last lost at home in regulation 5-2 decision to Chicago on Dec. 3, 2011.

Marchand and Milan Lucic scored in the first period to give the Bruins a 2-0 lead. Marchand pushed the lead to 4-2 midway through the third period with his 21st goal of the season.

Chris Kelly, who assisted on Lucic’s goal, broke a 13-game scoreless drought with his 15th goal of the season, tying a career high and putting the Bruins up 3-2 lead with 40 seconds left in the first period.

Thomas and the Blues’ Brian Elliott gave up a combined five goals on 16 shots in the first period.

Elliott, who entered the game with a league-leading 1.56 goals-against average, fell to 20-7-2 and lost for the second game in a row after a five-game winning streak.

NOTES: Referee Ian Walsh left the game early in the second period after suffering a cut that required medical attention. He returned 5:13 later. … The Blues open a six-game road trip Thursday night in Nashville. Coach Ken Hitchcock is winless (0-11-6-1) in his last 18 games in Nashville. … Elliott made his fourth successive start, tying a season high. … The Bruins were making their first to St. Louis since Nov. 23, 2009. … Boston has a league-best plus-33 scoring advantage in the third period.

Senators 5, Capitals 2

OTTAWA — Erik Karlsson and Milan Michalek each had three points Wednesday and the Ottawa Senators defeated the Washington Capitals 5-2.

John Carlson and Mathieu Perreault scored for the Capitals, who have lost three straight. Alex Ovechkin missed the game with a lower body injury and is listed as day-to-day.

Karlsson finished with a goal and two assists to set a new franchise record for assists by a defenseman in a season with 47.

The 21-year-old now has seven points in his last two games. His 60 points on the season give him a 20-point lead on Florida’s Brian Campbell for the NHL lead in scoring by a defenseman.

Michalek added two goals and an assist, while Chris Phillips, with his fourth goal in six games, also scored for Ottawa. Craig Anderson made 33 saves.

Nick Foligno scored into an empty net for Ottawa.

Tomas Vokoun allowed four goals on 11 shots before being replaced midway through the second period by Michal Neuvirth. He finished with 14 saves. Washington has been outscored 12-3 on its losing streak, and has lost six of its last seven.

Ottawa jumped out to a 2-0 lead on the back of Karlsson.

The smooth-skating defenseman opened the scoring at the nine-minute mark of the first with a shot that beat Vokoun through the legs. Karlsson then fed Michalek five minutes later and he made a great move around Dennis Wideman before beating Vokoun from in close.

Michalek added his second of the night on a deflection off Karlsson’s point shot on the power play early in the second. Michalek’s 27th goal of the season set a new career high.

Vokoun’s night came to an end after Phillips made it 4-0 on the power play midway through the period.

Despite being in a huge hole, Washington showed some jump in the third period to cut the lead to 4-2.

Carlson finally got the Capitals on the board with a power-play goal early in the period and Perreault made it 4-2 as the puck went off his face and past Anderson.

This was the final regular season meeting between the two teams. Washington took the first three.

NOTES: Ottawa has outscored its opponents 21-4 in its last four games. … With an assist on Karlsson’s goal, Jason Spezza extended his point streak (seven goals, nine assists) to seven games. … The Senators were without C Peter Regin (shoulder, out for season), C Jesse Winchester (concussion, indefinitely). D Matt Carkner and C Zenon Konopka were healthy scratches. … In addition to Ovechkin, the Capitals were without D Tom Poti (strained groin, indefinitely), C Nicklas Backstrom (concussion, indefinitely). Ds John Erskine and Roman Hamrlik were healthy scratches.