New England Patriots quarterback Mac Jones (10) is helped off the field after suffering a leg injury with less than two minutes to play in the second half of an NFL football game against the Baltimore Ravens, Sunday, Sept. 25, 2022, in Foxborough, Mass. (AP Photo/Michael Dwyer)

FOXBOROUGH, Mass. — Lamar Jackson threw four touchdown passes and ran for another score to help the Baltimore Ravens hold off the New England Patriots 37-26 on Sunday.

New England’s Mac Jones suffered a leg injury with less than two minutes to play, hopping off the field and heading straight to the locker room. He completed 22 of 32 passes for 321 yards but threw three interceptions.

Justin Tucker kicked a 56-yard field goal, the 50th of his career from 50 yards or more, as Baltimore claimed its first regular-season victory at New England in seven tries.

Despite being under pressure for most of the day and losing another member of his offensive line to an early injury, Jackson completed 18 of 29 passes for 218 yards with an interception. He rushed for 107 yards on 11 carries. Mark Andrews had eight catches for 89 yards and two TDs.

DeVante Parker had five catches for 156 yards for New England.

The Patriots had four turnovers on the day — Jones’ three picks and a late fumble by Nelson Agholor.

Trailing by a point at halftime, Jones came out firing in the third quarter. He completed a 36-yard pass to Parker to get into Ravens territory and followed it up with a 25-yard strike to Parker that put the ball on the 2.

The 7-play, 75-yard drive ended with Damien Harris’ 2-yard TD run that put the Patriots in front 20-14.

The Ravens responded in the ensuing series when Jackson found Josh Oliver from 1 yard out to conclude a 75-yard drive.

Following a quick punt by the Patriots, Jackson got free for a 38-yard run to get the ball back into the red zone. He then connected with Devin Duvernay from 4 yards out for another TD.

The Ravens got the ball right back after Jones’ pass intended for Parker was picked off by linebacker Josh Bynes. Baltimore moved the ball only 5 yards, but it was enough for Tucker’s long field goal, which increased the lead to 31-20.

The Patriots were successful on a fourth-and-1 from the 17 to help set up a 1-yard TD run by Rhamondre Stevenson. It trimmed the gap to 31-26 after a 2-point conversion try was unsuccessful.

New England got the ball back Rashod Bateman caught a 24-yard pass, then fumbled. Jabril Peppers recovered.

The Patriots took it back down to the Ravens 10, but Jones’ pass into the end zone overshot Parker and was intercepted by Marlon Humphrey.

A quick three-and-out and short punt by Baltimore gave the Patriots the ball back. But a 30-yard pass from Jones to Agholor ended with a strip from behind by Kyle Hamilton and recovery by Marcus Peters along the sideline with 5:45 left.

The Ravens capitalized, marching 73 yards over the next 2:35 to take a 37-26 lead on Jackson’s 9-yard TD run.

Baltimore’s offense was effective despite having to go deep into its depth chart because of injuries. The Patriots took advantage, sacking Jackson four times in the first half – three by Deatrich Wise.

Jackson was also intercepted early in the second quarter by Jonathan Jones, which New England turned into points when Jones scored on a 3-yard run.

For the Patriots, Nick Folk made a 35-yard field goal in the second quarter that was his 57th in a row from inside 50 yards — an NFL record.