FORT MYERS, Fla. — Joe Mauer made his first spring training start at first base for a Minnesota Twins split squad in a 2-1 win over the Boston Red Sox on Friday night.

The Twins’ regular catcher went 1 for 2 with a walk. First baseman Justin Morneau went 0 for 4 as the designated hitter.

Red Sox ace Jon Lester struck out two, walked one and hit two batters in in four innings. He gave up two runs and five hits in his fourth spring training start.

Andrew Miller, recovered from a shoulder setback and still vying for a spot in the Red Sox’s rotation, pitched a hitless inning.

CARDS 5, MARLINS 0: Marlins newcomer Mark Buehrle was tagged for five runs in 2 1-3 innings and the St. Louis Cardinals defeated Miami 5-0 Friday.

Buehrle allowed six hits and walked two in his second spring training start. He threw 70 pitches against what could be the Cardinals’ opening day lineup.

Matt Holliday hit his first home run of the spring and is batting .500 in exhibition play.

Cardinals starter Jake Westbrook tossed four shutout innings, allowing two hits.

St. Louis first baseman Lance Berkman returned to action for the first time since Sunday and doubled. He’d been out with a sore left knee.

TIGERS 9, METS 0: New York Mets ace Johan Santana struggled for the first time this spring and was pulled in the third inning of a loss to Detroit.

Out of the majors last year while recovering from shoulder surgery, Santana had not allowed a run in his first two exhibition starts. But the two-time Cy Young gave up five runs — four earned — on four hits and two walks in 2 2-3 innings. He didn’t have any strikeouts.

Santana retired his first four batters, but seven of the next 10 hitters reached base against the left-hander.

Detroit starter Rick Porcello threw four scoreless innings, giving up four hits and striking out three.

ORIOLES 3, TWINS 1: Nick Blackburn had another impressive start, striking out three and allowing just one hit in four scoreless innings for a Minnesota Twins split squad in a loss to Baltimore.

The right-hander, who is coming off an inconsistent, injury-slowed 7-10 season, has given up four hits and no runs through seven innings this spring.

Orioles first baseman Chris Davis, who struggled late last year with a slight right labrum tear after coming over in a trade from the Rangers, went 2 for 4 with a double.

Baltimore’s Chris Tillman gave up four hits and a run in three innings.

PIRATES 3, PHILLIES 2: Cliff Lee allowed two home runs in 4 2-3 innings and was out pitched by Kevin Correia, who gave up one hit in four scoreless and led Pittsburgh to a win over Philadelphia.

Starling Marte took Lee deep in the first and later singled against the former Cy Young winner. Lee allowed three runs on five hits and a walk. He struck out five.

Correia, Pittsburgh’s opening-day starter last year, breezed through a Philadelphia lineup without most of its stars. Hunter Pence was one of only a few Phillies regulars in the lineup, and he struck out twice in three at-bats.

YANKEES 4, NATIONALS 3: Gio Gonzalez pitched into the fourth inning and allowed one run for Washington in a loss to the New York Yankees on Friday.

Gonzalez gave up two hits and three walk in 3 1-3 innings. He had six strikeouts. The Nationals’ new starter called the outing “a good stepping stone.”

Alex Rodriguez hit a two-run homer for the Yankees. CC Sabathia was touched for three runs and six hits over three innings. Phil Hughes gave up three hits in four scoreless innings.

The Yankees announced Andy Pettitte has come out of retirement, signing a minor league contract with the team.

Washington manager Davey Johnson said right-hander Chien-Ming Wang, who strained his left hamstring fielding a grounder Thursday, will be out a couple weeks.

BLUE JAYS 5, RAYS 0: Ricky Romero pitched four hitless innings and Toronto beat Tampa Bay.

Jeff Niemann, in the three-way scramble for one of the last two spots in Tampa Bay’s rotation, gave up four runs in 3 1-3 innings. Niemann had allowed just two hits and no runs over five innings in two previous starts, but he gave up eight hits this time, including a pair of RBI singles to J.P. Arencibia.

Romero struck out four. Travis Snider hit his fourth spring home run, off Jhonny Nunez in the sixth inning.

GIANTS 3, CUBS 2: Eric Surkamp pitched four effective innings and San Francisco beat the Chicago Cubs.

Surkamp, who went 2-2 in six starts for San Francisco as a rookie last season, is a long shot to make the rotation this year. He gave up one run and four hits, striking out four.

Cubs starter Matt Garza allowed two runs and three hits in four innings.